Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
18/03/2024 The role of inequalities in asthma care and outcomes in England: a cohort study of people with asthma
01/03/2024 COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
06/02/2024 Effectiveness of COVID-19 vaccines on severe COVID-19 and post-acute cardiovascular events and diabetes following SARS-CoV-2 infection: A cohort study
29/01/2024 Quantifying the impact of the COVID-19 pandemic and the Kidney Failure Risk Equation on Chronic Kidney Disease care and outcomes in Primary Care
29/12/2023 Retrospective cohort analysis using Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) to investigate adherence to androgen deprivation therapy (ADT) in patients with prostate cancer
28/12/2023 Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes: cohort study on the effect of using common data models
28/12/2023 Trends in prescription of oral anticoagulants in elderly individuals with atrial fibrillation in UK primary care
28/12/2023 Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes in patients with atrial fibrillation: effect of using a common protocol only versus a syntactically harmonized Common Data Model
28/12/2023 Characterization of Pregnancy Outcomes in Women with Generalized Pustular Psoriasis
27/12/2023 Epidemiological analysis of inflammatory eye and central nervous system conditions and their risk factors, association with infectious and immune-mediated inflammatory diseases, and health impacts. A UK population-based observational study
27/12/2023 Incidence, Prevalence, and Predictors of Fibromyalgia in People with Inflammatory Arthritis: An Observational Cohort Study using the Clinical Practice Research Datalink Aurum.
27/12/2023 Reinforcement Learning approach to evaluate and rank AI models that use clinical parameters to predict hospitalisation and mortality of adults with Multiple Long-Term Conditions
27/12/2023 Evaluation of foot screening in primary care in people with diabetes in England
27/12/2023 Risks factors and causes of postnatal General Practitioner consultations and hospital admissions following perinatal mortality: a cohort study
22/12/2023 Incidence, prevalence, and characterisation of medicines with suggested drug shortages in Europe
20/12/2023 Measuring current practice and inequalities in type 2 diabetes treatment and intensification: a population-based cohort study
20/12/2023 Investigating the impact of SARS-CoV-2 on gastrointestinal illness using advanced linked data systems
20/12/2023 Monitoring the prescription in primary care of antibiotics for public health emergencies that may be at risk of shortages in the European Union
20/12/2023 Does flucloxacillin increase the risk of stroke and systemic embolism in patients who are already using direct oral anticoagulants?
19/12/2023 The effect of antiseizure medications on the effectiveness and safety of anticoagulants in patients with stroke: A population-based study in the United Kingdom.