Death rattle, defined as noisy breathing caused by the presence of mucus in the respiratory tract, is common among dying patients. Harriette van Esch, MD, from the Erasmus Medical Center, the Netherlands, and Jared R. Lowe, MD, from the University of North Carolina, join JAMA Associate Editor Ethan Basch, MD, to discuss evidence about use of prophylactic scopolamine butylbromide to reduce the death rattle.