Job Information
- Organisation/Company
- Leibniz Institute for Plasma Science and Technology
- Research Field
- PhysicsBiological sciences » BiologyChemistry » BiochemistryEngineering » Biomedical engineeringEngineering » Chemical engineering
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Germany
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 38-40
- Is the job funded through the EU Research Framework Programme?
- HE / MSCA
- Marie Curie Grant Agreement Number
- 101118430
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
The PlasmACT network brings together 5 beneficiaries and 10 associated partners, located in 5 different countries (Germany, France, Netherlands, Belgium, and Luxembourg). A total of eight Doctoral Candidates will enjoy a multi-disciplinary and international environment with plenty of training opportunities and exchange with all institutions involved in the network.
Scientific Background:
The quality of human (and veterinary) health care systems substantially depends on key innovations. Often, these were driven by the field of physics, followed by interdisciplinary and inter-sectorial actions in engineering, chemistry, biology, and medicine. By using beyond state-of-the-art plasma multijet technology, the primary technical objective of PlasmACT is to support skin cancer prevention by medical gas plasma therapy of Actinic Keratosis
DC1: Oxidation-driven processes in human keratinocytes analyzed by mass spectrometry
Description: The project assesses the biochemistry aspects of gas plasma treatment in actinic keratosis. This includes the analysis of protein expression and post-translational modifications, including oxidative modifications, of in vitro cultured cells obtained by this DC as well as specimens from animal experiments and patients obtained by other PlasmACT DCs. The research aspects potentially extend to immunopeptidomics analysis. Technically, the main method to be employed is ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry, and the project tasks the entire mass spectrometry workflow from sample generation, sample preparation, sample acquisition, and sample analysis. In addition, two secondments to an academic and industrial partner institution are already planned to broaden the network and differentiate the student's skills and knowledge. Furthermore, the project provides ample opportunities for professional exchange and networking with other academic and industrial partners.
Requirements:
- Master of Science in Biochemistry or Master of Engineering
- Mass spectrometry analysis, the main type of experiment in this project, requires a strong affinity to computer processes, software operation, and large data handling. Programming skills are an asset but are not required.
Supervisor: Prof. Sander Bekeschus
Institution: Leibniz Institute for Plasma Science and Technology (INP), ZIK plasmatis
Application deadline: 18.03.2024
Expected starting date: June 2024
DC2: Cell biology and inflammation in plasma-treated diseased keratinocytes
Description: The project assesses cell biology aspects of gas plasma treatment in actinic keratosis, mainly in several cell lines investigated in vitro. This includes the analysis of various parameters linked to cell viability and metabolism, and investigating the specific mode of cell death following gas plasma exposure. For this, quantitative microscopy based on high-content imaging as well as multi-color flow cytometry are utilized next to molecular biology tools. In addition, hallmarks of inflammation damage-associated molecular patterns that can potentially affect immune cells are investigated. This project will aid in cell biology and inflammatory tissue analysis obtained from other PlasmACT DCs. In addition, two secondments to an academic and industrial partner institution are already planned to broaden the network and differentiate the student's skills and knowledge. Furthermore, the project provides ample opportunities for professional exchange and networking with other academic and industrial partners.
Requirements:
- Master of Science in Biology or similar
Supervisor: Prof. Sander Bekeschus
Institution: Leibniz Institute for Plasma Science and Technology (INP), ZIK plasmatis
Application deadline: 30.04.2024
Expected starting date: 01.09.2024
DC5: The diagnostics of the plasma in interaction with targets relevant for medicine
Description:
This project will focus on the diagnostics of the plasma in interaction with targets relevant for the PlasmACT. One of the goals is to measure electric fields as close as possible to the target. However, other diagnostics will be employed to gather supporting data.
In addition, two secondments to an academic and industrial partner institution are already planned to broaden the network and differentiate the student's skills and knowledge. Furthermore, the project provides ample opportunities for professional exchange and networking with other academic and industrial partners.
Requirements:
- Master of Science, preferably in Physics
Supervisor: Prof. Ana Sobota
Institution: Eindhoven University of Technology, Department of Applied physics and science education
Application deadline: 18.03.2024
Expected starting date: June 2024
DC6: Plasma safety and effects on human patient samples and DNA-repair mechanisms
Description: The primary objective of this subproject is to test the biological safety of a cold plasma device for the use against actinic keratosis. This testing will be performed at different levels of complexity including cell culture models, in vivo rodent animal models, as well as patient-derived normal skin or actinic keratosis lesions (ex vivo). Cytotoxicity, mutagenicity, DNA-damage, and long-term adverse effects of the treatment will be assessed using cell biology and molecular biology assays as well as state-of-the-art high content imaging microscopy. Given the clinical research environment, the final aim is to support a study with a small volunteer cohort on tolerability aspects of the cold plasma device. In addition, two secondments to an academic and industrial partner institution are already planned to broaden the network and differentiate the student's skills and knowledge. Furthermore, the project provides ample opportunities for professional exchange and networking with other academic and industrial partners.
Requirements:
- Master of Science in Biology, Molecular Medicine, Biomedicine, Biochemistry or a related field
Supervisor: Prof. Steffen Emmert
Institution: University Medicine Rostock, Clinic and Policlinic for Dermatology and Venereology
Application deadline: 30.04.2024
Expected starting date: 01.09.2024
Requirements
- Research Field
- Chemistry » Biochemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
- Research Field
- Physics
- Education Level
- Master Degree or equivalent
- Research Field
- Engineering » Chemical engineering
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Biological engineering
- Education Level
- Master Degree or equivalent
- Research Field
- Engineering » Biomedical engineering
- Education Level
- Bachelor Degree or equivalent
The candidates should have a strong background in the fields mentioned above. The candidates should be able to work independently, take initiative, adopt critical judgment and demonstrate ability to work in a team. The project will include several network wide educational events and secondments, for which travel, communication and social skills are required. Proficiency in written and spoken English is crucial
For specific requirements please refer to the individual PhD descriptions.
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
Doctoral candidates are offered a competitive remuneration based on the MSCA allowances in line with theMSCA WP 2021-2022.
- Applicants must be doctoral candidates, i.e not already in possession of a doctoral degree at the date of recruitment.
- Mobility rule: researchers must not have carried out their main activity (e.g. work, studies) at the host country for more than 12 months in the 3 years immediately before their recruitment date.
- DC applicants must fulfil the local recruiting requirements
Candidates should apply with PlasmACT DN application form available on the project website (https://plasmact.eu/vacancies/) and transcripts before the deadline indicated for each DC position. Applicants applying for a position in the GREMI laboratory (DC3 and DC4) must obtain a security clearance issued by the French Ministry of Defense in order to work there. Therefore, applicants must submit their application form together with a completed ZRR application (also available on the project website) including a scan of their identity card/passport and a CV.
Submitted applications will be evaluated according to the European Code of Conduct for Recruitment (https://euraxess.ec.europa.eu/jobs/charter/code).
Shortlisted candidates will be invited for interviews 4 weeks after the deadline. Shortlisted candidates will be notified about the selection process outcome.
Applicants interested in the position will also have to apply to the PhD Program. Employment will be conditioned by acceptance to the program.
- Website for additional job details
Work Location(s)
- Number of offers available
- 2
- Company/Institute
- Leibniz Institute for Plasma Science and Technology (INP)
- Country
- Germany
- City
- Greifswald
- Street
- Felix-Hausdorff-Str 2
- Geofield
- Number of offers available
- 1
- Company/Institute
- Eindhoven University of Technology, Department of Applied physics and science education
- Country
- Netherlands
- City
- Eindhoven
- Postal Code
- 5612 AP
- Geofield
- Number of offers available
- 1
- Company/Institute
- University Medicine Rostock, Clinic and Policlinic for Dermatology and Venereology
- Country
- Germany
- City
- Rostock
- Street
- Schillingallee 35
- Geofield
Where to apply
- Website
Contact
- City
- Greifswald
- Website
- Street
- Felix-Hausdorff-Straße 2
- Postal Code
- 17489
- info@plasmact.eu