Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - Novel insights and future directions in diagnosis and therapy<sup/>

Trends Cardiovasc Med. 2019 Jan;29(1):22-26. doi: 10.1016/j.tcm.2018.05.010. Epub 2018 Jun 4.

Abstract

We provide an up-to-date overview of current topics surrounding oxidized low-density lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at risk of cardiovascular disease and atherosclerotic plaques with unfavorable characteristics. We discuss the potential of oxLDL and anti-oxLDL antibodies as serum biomarkers of cardiovascular disease and emerging studies examining the targeting of arterial oxLDL for imaging and therapeutic delivery.

Keywords: Atherosclerosis; Oxidized low-density lipoprotein; Vulnerable plaque.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies / administration & dosage
  • Antibodies / immunology
  • Antibodies / metabolism*
  • Arteries / diagnostic imaging
  • Arteries / immunology
  • Arteries / metabolism*
  • Arteries / pathology
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism*
  • Atherosclerosis / therapy
  • Biomarkers / metabolism
  • Humans
  • Immunization / methods
  • Lipoproteins, LDL / administration & dosage
  • Lipoproteins, LDL / immunology
  • Lipoproteins, LDL / metabolism*
  • Molecular Imaging / methods
  • Plaque, Atherosclerotic
  • Predictive Value of Tests
  • Prognosis
  • Vaccines / administration & dosage
  • Vaccines / immunology

Substances

  • Antibodies
  • Biomarkers
  • Lipoproteins, LDL
  • Vaccines
  • oxidized low density lipoprotein