Lipoprotein(a) in Alzheimer, Atherosclerotic, Cerebrovascular, Thrombotic, and Valvular Disease: Mendelian Randomization Investigation

Circulation. 2020 Jun 2;141(22):1826-1828. doi: 10.1161/CIRCULATIONAHA.120.045826. Epub 2020 Jun 1.

Authors

Susanna C Larsson^{1

2}, Dipender Gill³, Amy M Mason⁴, Tao Jiang⁴, Magnus Bäck^{5

6}, Adam S Butterworth^{4

7

8}, Stephen Burgess^{4

9}

Affiliations

¹ Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine (S.C.L.), Karolinska Institutet, Stockholm, Sweden.
² Department of Surgical Sciences, Uppsala University, Sweden (S.C.L.).
³ Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Hospital, Imperial College London, United Kingdom (D.G.).
⁴ British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom (A.M.M., T.J., A.S.B., S.B.).
⁵ Department of Medicine, Center for Molecular Medicine (M.B.), Karolinska Institutet, Stockholm, Sweden.
⁶ Heart and Vascular Theme-Division of Valvular and Coronary Disease, Karolinska University Hospital, Stockholm, Sweden (M.B.).
⁷ National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge (A.S.B.), University of Cambridge, United Kingdom.
⁸ Health Data Research UK Cambridge, Wellcome Genome Campus (A.S.B.), British Heart Foundation Centre of Research Excellence (A.S.B.), University of Cambridge, United Kingdom.
⁹ MRC Biostatistics Unit (S.B.), University of Cambridge, United Kingdom.

No abstract available

Keywords: Alzheimer disease; Mendelian randomization analysis; atherosclerosis; heart valve diseases; lipoprotein(a); stroke.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / blood*
Alzheimer Disease / etiology
Causality
Cerebrovascular Disorders / blood*
Cerebrovascular Disorders / etiology
Coronary Disease / blood
Coronary Disease / etiology
Dementia, Vascular / blood
Dementia, Vascular / etiology
Heart Valve Diseases / blood*
Heart Valve Diseases / etiology
Humans
Lipoprotein(a) / blood*
Lipoprotein(a) / genetics
Mendelian Randomization Analysis
Odds Ratio
Polymorphism, Single Nucleotide
Thrombosis / blood*
Thrombosis / etiology
White People / genetics

Substances

Lipoprotein(a)

Grants and funding