Authors
Megan Thomas, Timea Szentgyorgyi, Lucy D Vanes, Elias Mouchlianitis, Erica F Barry, Krisna Patel, Katie Wong, Dan Joyce, Sukhwinder Shergill
Publication date
2021/1/1
Journal
Psychiatry Research
Volume
295
Pages
113607
Publisher
Elsevier
Description
Approximately one third of psychosis patients fail to respond to conventional antipsychotic medication, which exerts its effect via striatal dopamine receptor antagonism. The present study aimed to investigate impaired cognitive control as a potential contributor to persistent positive symptoms in treatment resistant (TR) patients. 52 medicated First Episode Psychosis (FEP) patients (17 TR and 35 non-TR (NTR)) took part in a longitudinal study in which they performed a series of cognitive tasks and a clinical assessment at two timepoints, 12 months apart. Cognitive performance at baseline was compared to that of 39 healthy controls (HC). Across both timepoints, TR patients were significantly more impaired than NTR patients in a task of cognitive control, while performance on tasks of phonological and semantic fluency, working memory and general intelligence did not differ between patient groups. No significant …
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